Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

3.4K
Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon...
3.4K
Cell Migration01:09

Cell Migration

17.1K
Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
17.1K
Cytoskeletal Coordination in Cell Migration01:32

Cytoskeletal Coordination in Cell Migration

4.8K
A migrating cell changes its shape during the cyclic events of attachment and detachment from the substratum and repositions the cell organelles correspondingly. These complex events are orchestrated by the dynamic cytoskeletal network comprising actin filaments, intermediate filaments, and microtubules. Cytoskeletal crosstalk — the direct and indirect communication between the different components — is crucial for this coordination. Direct communication involves various linker...
4.8K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Transcriptomics of type 1 diabetes progression: a validation study in newly diagnosed patients.

EBioMedicine·2026
Same author

Clarifying the scope and capabilities of ROTS in differential expression analysis.

Bioinformatics (Oxford, England)·2026
Same author

Joint modeling of longitudinal and time-to-event data for dynamic disease risk prediction using proteomics.

Protein science : a publication of the Protein Society·2026
Same author

REACTOR: REgulon Activity analysis and Comparison Tool for single-cell transcriptOmics Research.

Bioinformatics (Oxford, England)·2026
Same author

Therapeutic TG2 inhibition reverses systemic multiomic dysregulation in celiac disease.

BMC medicine·2026
Same author

Testosterone Exposure During Fetal Masculinization Programming Window Determines the Kidney Size in Adult Mice.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology·2026

相关实验视频

Updated: Jul 18, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
00:10

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.3K

从单个细胞数据中推断细胞连接引导的轨迹推断.

Johannes Smolander1, Sini Junttila1, Laura L Elo1,2

  • 1Turku Bioscience Centre, University of Turku and Åbo Akademi University, 20520 Turku, Finland.

Bioinformatics (Oxford, England)
|August 25, 2023
PubMed
概括
此摘要是机器生成的。

托特姆是一个R包,简化了从单细胞RNA测序数据推断细胞分化轨迹的推断. 它自动选择最佳的树状轨迹,并确定关键的细胞分支点,减少了对广泛的方法专业知识的需求.

更多相关视频

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
10:55

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

8.7K
Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
04:24

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

Published on: February 13, 2011

9.6K

相关实验视频

Last Updated: Jul 18, 2025

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules
00:10

Single-Molecule Tracking Microscopy - A Tool for Determining the Diffusive States of Cytosolic Molecules

Published on: September 5, 2019

8.3K
Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
10:55

Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

Published on: December 16, 2017

8.7K
Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns
04:24

Studying Cell Rolling Trajectories on Asymmetric Receptor Patterns

Published on: February 13, 2011

9.6K

科学领域:

  • 计算生物学 计算生物学
  • 基因组学就是基因组学.
  • 生物信息学是一种生物信息学.

背景情况:

  • 单细胞RNA测序 (scRNA-seq) 为研究分化等细胞过程提供了高分辨率数据.
  • 轨迹推断方法对于建模细胞分化至关重要,但通常需要手动选择和参数调整.
  • 由于生物系统的复杂性和数据的可变性,精确的轨迹推断具有挑战性.

研究的目的:

  • 介绍Totem,一个开源的R包,用于从scRNA-seq数据中自动推断树状轨迹.
  • 提供一个易于使用的工具,减少用于轨迹分析所需的方法专业知识.
  • 为了能够有效地识别分支点和细胞分化的里程碑.

主要方法:

  • 托特姆生成了众多的集群结果,并使用最小跨越树来估计它们的拓.
  • 细胞连接率是为了评估推断轨迹之间的稳定性和关系而计算的.
  • 该套件有助于自动选择生物学上最合理的轨迹.

主要成果:

  • 托特姆自动从单细胞数据中选择树状轨迹.
  • 细胞连接分析有助于视觉识别关键分支点和发展里程碑.
  • R包提供了一个快速和用户友好的轨迹推理方法,最大限度地减少了对深入方法知识的需求.

结论:

  • 托特姆简化了从scRNA-seq数据分析细胞分化轨迹的过程.
  • 该包通过突出关键细胞事件来提高分化过程的解释性.
  • 托特姆为更广泛的研究人员提供了先进的轨迹推断技术.