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相关概念视频

Genomics02:02

Genomics

36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Genomic DNA in Eukaryotes00:58

Genomic DNA in Eukaryotes

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Eukaryotes have large genomes compared to prokaryotes. To fit their genomes into a cell, eukaryotic DNA is packaged extraordinarily tightly inside the nucleus. To achieve this, DNA is tightly wound around proteins called histones, which are packaged into nucleosomes that are joined by linker DNA and coil into chromatin fibers. Additional fibrous proteins further compact the chromatin, which is recognizable as chromosomes during certain phases of cell division.
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Organization of Genes02:07

Organization of Genes

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Overview
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基因组学:将基因组学的高性能和可读性与Go结合在一起.

Eric H Au1, Christiana Fauci1,2, Yanting Luo1,2

  • 1Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC 27710, United States.

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基因组学 (Gonomics) 是Go中的一个新的开源软件集合,为基因组分析提供高性能和可读性. 它支持各种文件格式,并使生物信息学可灵活开发管道.

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科学领域:

  • 生物信息学是一种生物信息学.
  • 计算生物学 计算生物学
  • 基因组学就是基因组学.

背景情况:

  • 基因组软件经常迫使人们在编译语言性能和解释语言可访问性之间做出选择.
  • 现有的工具可能无法满足对高性能生物信息学资源日益增长的需求.

研究的目的:

  • 介绍Gonomics,这是一个开源的生物信息图书馆和命令行程序集合.
  • 使用Go编程语言在基因组数据分析中统一性能和可读性.

主要方法:

  • 使用Go编程语言实现了Gonomics.
  • 开发了模块化库,用于阅读,写入和处理基因组文件格式 (FASTA,FASTQ,BED,BEDPE,SAM,BAM,VCF).
  • 启用格式转换和互操作性.

主要成果:

  • 基因组学为基因组分析提供了统一的解决方案,平衡性能和易用性.
  • 为开发定制生物信息学工具提供灵活的平台.
  • 方便创建复杂,高性能的分析管道.

结论:

  • 基因组学解决了基因组软件中的性能-可访问性冲突.
  • 它是基因组学和生物信息学研究人员的一个有价值的开源资源.
  • Go的实施确保了高效和可读的基因组数据处理.