单价性SARS-CoV-2mRNA疫苗在糖尿病和控制儿科患者中没有增强欧米克龙特异性免疫反应
Alan Sariol1, Molly A Vickers1, Shannon M Christensen2
1Department of Microbiology and Immunology, University of Iowa, Iowa City, Iowa, USA.
患有1型糖尿病 (T1D) 的儿童对COVID-19疫苗有强大的免疫反应,与健康同龄人相比. 然而,提升剂意外地未能显著增加对T1D儿童对Omicron变异的中和抗体.
科学领域:
- 免疫学 免疫学 免疫学
- 儿科 儿科 儿科
- 内分泌学 在内分泌学.
背景情况:
- 关于儿童群体中SARS-CoV-2疫苗免疫性,特别是1型糖尿病 (T1D) 患者的数据有限.
- 患有T1D的儿童患重症感染的风险更高,这强调了需要了解他们的疫苗反应的必要性.
研究的目的:
- 与非糖尿病对照组相比,研究COVID-19 mRNA疫苗在T1D儿童中的免疫性.
- 评估第三剂疫苗对抗体和T细胞对SARS-CoV-2变种的反应的影响.
主要方法:
- 对35名患有T1D和23名接受COVID-19mRNA疫苗的儿童进行比较研究.
- 测量SARS-CoV-2中和抗体标位和尖端蛋白特异性T细胞反应.
- 在初级疫苗接种系列和第三次强剂后对反应的分析.
主要成果:
- 患有T1D的儿童在初次接种疫苗后表现出类似的中和抗体标位和T细胞对对照细胞的反应.
- 第三次增强剂量增加了对祖先SARS-CoV-2菌株的中和抗体标位.
- 意想不到的是,增强剂量并没有显著提高儿童中对Omicron变异的中和抗体标位,与成人不同.
结论:
- COVID-19 mRNA疫苗在患有T1D的儿童和健康儿童中引起了相似的免疫反应.
- 增强剂对祖先菌株有效,但对T1D儿科群体的Omicron变体具有有限的增强效果.
- 需要进一步的研究来优化T1D儿童针对新出现的SARS-CoV-2变种的疫苗接种策略.
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