抗艾滋病毒药物洛皮纳维尔/里托纳维尔激活苦味受体
Shurui Chen1, Xinyi Zhou1, Yongcheng Lu1
1Department of Pharmaceutical Sciences, School of Pharmacy, Bouvé College of Health Sciences, Northeastern University, Boston, MA 02115, United States.
Chemical senses
|August 25, 2023
概括
洛皮纳维尔和利托纳维尔 (LPV/r),是儿童的关键艾滋病毒药物,味道苦,阻碍了治疗的坚持. 这项研究确定了LPV/r激活的特定苦味受体,为改进,儿童友好的配方铺平了道路.
科学领域:
- 药理学 药理学是指药理学的学科.
- 味觉受体研究 味觉受体研究
- 儿童艾滋病毒治疗方法
背景情况:
- 洛皮纳维尔和利托纳维尔 (LPV/r) 是世卫组织推为儿童使用的第一线抗艾滋病毒药物.
- 液体配方用于儿科剂量,但苦味会损害治疗的坚持和疗效.
- 小儿艾滋病毒药物的味道不佳会对存活率产生负面影响.
研究的目的:
- 阐明lopinavir和ritonavir激活苦味受体 (TAS2Rs) 的分子机制.
- 确定涉及这些必不可少的抗艾滋病毒药物的苦味感知的特定TAS2R.
- 为开发可口的儿科艾滋病毒配方提供信息.
主要方法:
- 使用动员试验来测量TAS2R激活.
- 这项研究描述了lopinavir,ritonavir和各种TAS2Rs之间的相互作用.
- 进行了对药物激活苦味受体的系统选.
主要成果:
- 洛皮纳维尔被发现可以激活TAS2R1和TAS2R13.
- 里托纳维尔激活了TAS2R1,TAS2R8,TAS2R13和TAS2R14. 这两种类型.
- 这些发现确定了LPV/r.受影响的特定苦味路径.
结论:
- 了解洛皮纳维尔和里托纳维尔的TAS2R激活对于改善儿科艾滋病毒药物可口性至关重要.
- 针对这些特定的苦味受体可能会导致开发有效的口味掩饰策略.
- 开发适合儿童的配方,减少苦味,对于提高儿科艾滋病毒的治疗效果和治疗效果至关重要.
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