在胃肠道恶性瘤中准确的外科手术治疗
Michael J Glover1, Jeffrey Bien1, Christopher T Chen1
1Stanford University School of Medicine, Stanford, CA.
JCO precision oncology
|August 25, 2023
概括
精密外科手术周围疗法根据胃肠道 (GI) 癌症的分子洞察力量身定制癌症治疗方法. 这种方法旨在通过选择最佳的外科手术期间药物来改善可切除疾病患者的治疗结果.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 基因组学就是基因组学.
背景情况:
- 精密瘤学使用分子数据指导癌症治疗.
- 精密外科手术周围治疗侧重于分子识别可能从切除癌症的外科手术周围药物中受益的患者.
- 这种方法越来越多地用于局部胃肠道 (GI) 癌症.
研究的目的:
- 总结一下胃肠道癌的精确外科手术期治疗的现状.
- 突出这一领域未来创新的领域.
主要方法:
- 对PubMed文章 (2017-2023) 的文献综述,使用诸如"辅助剂"",术后","新辅助剂"和"精确药物"等术语来治疗肠道恶性瘤.
- 包括通过ClinicalTrials.gov (2023年1月) 访问的正在进行的临床试验数据.
主要成果:
- 新兴范式包括使用循环瘤DNA进行最小残留疾病检测.
- 术后免疫疗法对不匹配修复缺陷疾病具有前途,可能降低毒性.
- 在转移环境中活跃的分子向药物可能有利于可治愈的胃肠道癌症.
结论:
- 胃肠道癌的精密外科治疗是一个不断发展的领域,有着早期有希望的数据.
- 目前正在进行的研究预计将推进精密外科手术治疗对可切除的肠道恶性瘤患者的应用.
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