一种"SURFin'白血病":急性淋巴细胞白血病伪装成不分化的复发性发烧综合征
Laura De Nardi1, Martina D'Agostin1, Samuele Naviglio2
1Department of Medical Surgical and Health Science, University of Trieste.
Journal of pediatric hematology/oncology
|August 25, 2023
概括
儿科周期性发烧可能是急性淋巴细胞白血病 (ALL) 的早期迹象,而不仅仅是自身炎症性疾病. 早期对ALL的怀疑至关重要,以避免在患有反复发烧的儿童中误诊.
科学领域:
- 儿科瘤学 儿科瘤学
- 类风湿病学 类风湿病学
- 血液学 血液学 血液学
背景情况:
- 周期性发烧是一种常见的儿童症状,通常与自身炎症性疾病有关.
- 然而,发烧也可能是儿科恶性瘤的非典型表现.
研究的目的:
- 为了突出急性淋巴细胞白血病 (ALL) 的罕见表现,定期发烧.
- 强调在患有复发性不明原因发烧的儿童中考虑恶性瘤的重要性.
- 为了防止诊断延迟,并改善患者的治疗结果.
主要方法:
- 一个3岁男孩患有急性淋巴细胞白血病的病例报告.
- 详细的临床病史,包括4个月的复发发烧和关节疼痛.
- 差异诊断过程,最初考虑不分化的复发性发烧综合征.
主要成果:
- 患者最初出现了模仿周期性发烧综合征的症状.
- 随后出现白血病特异性症状导致了正确的诊断.
- 这一案例强调了当发烧是主要症状时,误诊的可能性.
结论:
- 急性淋巴细胞白血病可以异常呈现,有周期性发烧和关节疼痛.
- 在患有不明原因的周期性发烧的儿童中,对恶性瘤的高度怀疑指数是必要的.
- 及时识别白血病可以避免诊断错误,改善治疗开始.
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