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定义系统化疗在局部和高级尾腺癌中的作用

M C Strach¹, B Chakrabarty², R T Nagaraju³

¹Colorectal and Peritoneal Oncology Centre, The Christie NHS Foundation Trust, Manchester; Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK; Faculty of Medicine and Health, The University of Sydney, Darlington, Australia.

|August 25, 2023

概括

附录腺癌 (AAs) 是罕见的. 系统化疗显著改善了阳性淋巴结的AA患者的存活率,特别是与细胞还原性手术和高热性腹膜内化疗 (HIPEC) 结合使用时.

科学领域:

手术瘤学手术瘤学
胃肠道瘤学胃肠道瘤学
腹腔周围的恶性瘤

背景情况:

附录腺癌 (AAs) 是不常见的恶性瘤,倾向于腹转移 (PMs).
晚期呈现是常见的,需要评估治疗策略.
细胞还原性手术 (CRS) 与高热性腹腔内化疗 (HIPEC) 是一个关键的治疗方式.

研究的目的:

评估尾腺癌患者接受CRS治疗的结果.
确定全身化疗在管理PM的AA中的具体作用和益处.
评估影响AA患者生存的预后因素.

主要方法:

根据世卫组织2019年标准进行前性数据收集和分类.
评估细胞还原的完整性 (CC评分) 和HIPEC的管理 (米托米辛C).
使用卡普兰-梅尔和考克斯回归分析系统化疗时间 (前期,新辅助,辅助,缓解) 和生存率.

主要成果:

在216名患者中,有182名患者 (84%) 接受了CRS/HIPEC治疗,其中80%的患者达到CC0-1.
系统化疗给了队列中的45%,包括80%的淋巴结阳性患者.
平均整体生存时间为122个月. 阳性淋巴结从全身化疗中显著受益 (P < 0.0019).

结论:

带有阳性淋巴结的尾腺癌患者表现出系统化疗的最大益处.
腹癌的分期 (等级) 和非细胞性粘素的缺失是关键的预后指标.
CRS/HIPEC为精选的AA患者提供了很好的结果,特别是那些患有较低级别腹疾病的患者.

关键词:

附录腺癌瘤附录癌症是什么附录癌症是什么化疗化疗是一种化学疗法.腹膜转移的发生.治疗的结果.

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