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长效的莱纳卡帕维尔可以保护子免受性热带艾滋病毒的静脉挑战

Adrienne E Swanstrom¹, Robert J Gorelick¹, Jorden L Welker¹

¹AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

|August 25, 2023

概括

长效莱纳卡帕维尔 (LEN) 在体外表现出强烈的活性,并为猪尾提供了对类热带HIV-1挑战的完整保护. 这些发现支持开发LEN用于人类暴露前预防 (PrEP).

科学领域:

病毒学病毒学
药理学药理学是指药理学的学科.
灵长类动物模型

背景情况:

莱纳卡帕维尔 (LEN) 是一种针对多药耐药性HIV-1的第一类HIV囊抑制剂.
目前正在对LEN进行HIV-1暴露前预防 (PrEP) 的研究.
在猪尾 (PTM) 中的一种猿类热带HIV-1克隆 (stHIV-A19) 作为评估LEN PrEP的相关模型.

研究的目的:

评估LEN对stHIV-A19.9的体外疗效.
在PTM中评估皮下LEN的药理动力学.
为了确定LEN PrEP对stHIV-A19的体内保护疗效的挑战.

主要方法:

在PTM细胞中确定了体外LEN对stHIV-A19的功效.
皮下LEN的药理动力学在原始的PTM中进行了评估.
先前的PTM接受了一次LEN或载体的皮下注射,随后进行stHIV-A19挑战.

主要成果:

在体外,LEN对stHIV-A19具有强烈的抗病毒活性.
皮下LEN在PTM中实现了持续的血药物暴露.
所有接受LEN治疗和对照PrEP的动物都受到感染的保护,而车辆对照被感染.

结论:

stHIV-A19/PTM模型是评估LEN PrEP的一个有价值的工具.
长期起作用的LEN显示出在人类中有效的HIV-1 PrEP的潜力.

关键词:

卡普西德 (Capsid) 是一种状的鱼.艾滋病病毒艾滋病病毒艾滋病病毒澳门澳门澳门澳门非人类灵长类的灵长类.这就是为什么PrEP是PrEP.暴露前预防暴露前预防

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