在患有多囊性卵巢综合征的患者中,失调的Tfr/Tfh2细胞
Xiaofang Xuan1, Chunmei Ye2, Jiwei Zhao3
1Laboratory Medicine Center, Department of Clinical Laboratory, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
Journal of reproductive immunology
|August 25, 2023
概括
多囊卵巢综合征 (PCOS) 涉及改变的Tfh2和血细胞,其中Tfr细胞较低. Tfh2和Tfr细胞水平与和益生菌素相关,为PCOS免疫病原发生提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
- 生殖医学 生殖医学
背景情况:
- B细胞与多囊性卵巢综合征 (PCOS) 病原发生有关.
- 毛囊T辅助细胞 (Tfh) 极大地影响B细胞抗体的产生和幽默免疫.
- 在PCOS中Tfh细胞的作用仍然在很大程度上未被研究.
研究的目的:
- 在PCOS患者中调查Tfh细胞子集和B细胞子集的频率.
- 在PCOS中分析激素水平和Tfh/B细胞子集之间的关联.
- 阐明涉及Tfh和B细胞的PCOS免疫病原发生.
主要方法:
- 在21名PCOS患者和15名健康对照者中,使用流细胞计测来确定Tfh和B细胞子集 (Tfh1,Tfh2,Tfh17,原始B细胞,记忆B细胞,血细胞) 的频率.
- 使用免疫发光法测量了荷尔蒙水平 (FSH,LH,,益生素,雌激素,孕激素).
- 进行了统计分析,以将激素水平与细胞子集频率相关联.
主要成果:
- 在PCOS患者和对照人群之间,总Tfh细胞没有显著差异.
- 在PCOS患者中观察到Tfh2细胞和血细胞的百分比明显更高.
- 在PCOS患者中发现Tfr细胞和Tfr/Tfh2比率的频率明显较低.
- 与水平正相关的Tfh2细胞百分比.
- Tfr细胞百分比和Tfr/Tfh2比率与丸激素和益生菌度正相关.
结论:
- 结核复合综合症与失调的Tfh/Tfr细胞群相关.
- 升高的Tfh2和血细胞,以及降低的Tfr细胞,可能会导致PCOS免疫病原发生.
- Tfh2和Tfr细胞与和益生菌素的相关性凸显了它们在PCOS病理生理学中的潜在作用.
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