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在Aplysia的养网络中,持续的调节行动和任务切换

Elizabeth C Cropper¹, Matthew Perkins¹, Jian Jing²

¹Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY 10029, USA.

Current opinion in neurobiology

|August 25, 2023

概括

神经调节器持续改变网络活动,影响任务切换. 在Aplysia养电路中,从摄入到消化的切换得到促进,而由于多个电路参数,从消化到摄入的切换受到阻碍.

科学领域:

神经科学是一个神经科学.
系统神经科学系统神经科学
计算神经科学是一种神经科学.

背景情况:

多功能神经网络是由神经调节器调节的,它们会诱导网络活动的持续变化.
持续的神经调节效应引发了关于网络在不同活动模式之间灵活切换任务的能力的问题.

研究的目的:

为了研究持续的神经调节如何影响Aplysia养电路中的任务切换.
分析神经系统中不对称的任务切换偏差背后的机制.

主要方法:

对Aplysia养回路的现有研究进行审查.
对影响电路动态的神经调节机制的分析.
对控制不同行为状态 (摄入和消化) 的参数进行比较.

主要成果:

在Aplysia料电路中的任务切换表现出不对称性.
从摄入到摄入的切换是由神经调节 (负偏差) 阻碍的.
从摄入到消化的切换是容易的 (积极的偏差),摄入促进了随后的消化.

结论:

在任务切换中观察到的不对称性归因于存在多个集的egestive电路参数.
了解这些偏差可以了解神经调节器对神经回路的灵活控制.

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