在化疗后患有晚期非小细胞肺癌的患者中,大脑葡萄糖代谢模式异常:一项回顾性PET研究
Jie Yu1, Xiaoling Cao1, Renwei Zhou1
1Department of Nuclear Medicine, The Fifth Affiliated Hospital of Sun Yat-sen University, Sun Yat-sen University, Zhuhai, Guangdong, China.
Brain research bulletin
|August 25, 2023
概括
晚期非小细胞肺癌的化疗会导致大脑代谢异常,治疗后可能会有所改善. 18F-FDG PET/CT可以评估这些大脑功能变化.
科学领域:
- 神经科学是一个神经科学.
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 化疗是高级非小细胞肺癌 (NSCLC) 的基石治疗方法.
- 化疗的潜在神经毒性会影响大脑功能和新陈代谢.
- 了解化疗对大脑新陈代谢的时间影响对于患者管理至关重要.
研究的目的:
- 调查化疗对高级NSCLC患者大脑葡萄糖代谢的急性和慢性影响.
- 评估不同化疗周期持续时间对大脑代谢活动的影响.
- 探索18F-FDG PET/CT在评估化疗诱导的大脑变化的实用性.
主要方法:
- 分析了接受18F-FDG PET/CT治疗的73名晚期NSCLC患者.
- 患者被分为急性 (6个月内) 和慢性 (6个月以上) 化疗后组.
- 统计参数映射 (SPM) 用于比较患者组和健康对照组之间的大脑代谢.
主要成果:
- 化疗导致大脑新陈代谢发生改变,包括各种区域的超新陈代谢和低新陈代谢.
- 与慢性组相比,急性化疗效应组中代谢异常更为明显.
- 异常的数量与越来越多的化疗周期没有直接相关.
结论:
- 化疗在晚期NSCLC患者中诱导持续的异常大脑代谢模式.
- 这些代谢异常在化疗完成后,往往会随着时间的推移而减少.
- 18F-FDG PET/CT是评估化疗相关的大脑功能变化和指导治疗时间的潜在工具.
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