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Updated: Jul 18, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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以TRDMT1为媒介的RNA C-5甲基化作为抗癌疗法的新目标

Anna Lewinska1, Jagoda Adamczyk-Grochala1, Maciej Wnuk1

  • 1Institute of Biotechnology, College of Natural Sciences, University of Rzeszow, Pigonia 1, 35-310 Rzeszow, Poland.

Biochimica et biophysica acta. Reviews on cancer
|August 25, 2023
PubMed
概括

在癌症中,RNA的修改会发生变化. 酶TRDMT1 (DNMT2) 甲基化RNA,影响癌症的进展和稳定性. 抑制TRDMT1可能会提高癌症治疗的有效性.

关键词:
对抗癌症的策略.化学疗法诱导的衰老.遗传的不稳定性 遗传的不稳定性在RNAC-5甲基化过程中.在TRDMT1/DNMT2中使用.

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