双相情感障碍青少年的奖励处理神经异常:一项ERP研究
Joshua J Stim1, Erin L Maresh2, Abraham C Van Voorhis3
1Minneapolis VA Health Care System, Minneapolis, MN, USA; Department of Psychiatry and Behavioral Sciences, University of Minnesota, Twin Cities, USA.
Biological psychology
|August 25, 2023
概括
患有双相情感障碍 (BD) 的青少年在奖励处理方面表现出微妙的神经差异,特别是在预期和从反中学习时的注意力. 这些发现与成人BD模式不同,表明了独特的发育轨迹.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 青少年出现双相情感障碍 (BD) 与较差的成年结果有关.
- 一个领先的模型意味着在BD中存在失调的行为方法系统 (BAS).
- 青春期涉及与BAS相关的大脑区域的显著神经发育变化.
研究的目的:
- 研究BD青少年与健康同龄人之间在奖励处理中的神经差异.
- 在奖励预期和反过程中,检查与行为方法系统 (BAS) 相关的事件相关潜力 (ERP).
- 探索年龄,性别和诊断组如何影响这些神经反应.
主要方法:
- 在BD (n=43) 和对照 (n=56) 的青少年中,在货币激励延迟 (MID) 任务中比较ERP (N1,P3,FRN).
- 使用层次线性模型分析了预测暗示和反相关的神经活动.
- 研究了诊断组,MID状态,性别和年龄对ERP振幅的影响.
主要成果:
- 患有BD的青少年在预期损失期间与收益/平衡试验相比显示出更大的N1幅度.
- 患有BD的青少年在所有条件下表现出较小的反相关负面性 (FRN) 幅度.
- 微妙的,非无处不在的神经异常在奖励预期和反学习被观察到青少年BD.
结论:
- 与健康同龄人相比,患有BD的青少年在奖励处理中显示出明显的,微妙的神经模式.
- 这些神经差异涉及早期的注意力过程和奖励学习,但不是在成年人中看到的整体过敏.
- 研究结果表明,在青少年开始的BD中,BAS中存在独特的神经发育变化.
更多相关视频
05:04An Electrophysiology Protocol to Measure Reward Anticipation and Processing in Children
Published on: October 4, 2018
7.0K
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.7K
相关概念视频
01:30Bipolar Disorder
105
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
105
01:30Attention-Deficit/Hyperactivity Disorder
131
Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings....
131