治疗失败:系统审查和元分析
Lawrence Mbuagbaw1,2,3, Behnam Sadeghirad2,3,4, Rebecca L Morgan2,5,6
1Biostatistics Unit/The Research Institute, St Joseph's Healthcare, Hamilton, ON, Canada.
The British journal of dermatology
|August 25, 2023
概括
的治疗失败,影响15.2%的患者,因地区和时间而异. 与单次剂量相比,第二剂艾弗梅克丁显著降低了失效率.
科学领域:
- 皮肤病学 皮肤病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 疹治疗失败是疹发病率上升的一个重要因素.
- 治疗失败的区域和时间变化及其预测因素尚未得到充分理解.
研究的目的:
- 系统地审查治疗失败的流行情况.
- 调查与患者治疗失败相关的因素.
主要方法:
- 随机,准随机和观察性研究的系统审查和随机效应元分析.
- 在多个数据库 (MEDLINE,EMBASE等) 进行了搜索. 从开始到2021年8月.
- 包括使用甲氨酸,甲胺和其他药物治疗的研究,测量治疗失败.
主要成果:
- 整体治疗失败率为15.2%,具有显著的区域差异 (西太平洋地区最高).
- 通过口服艾弗梅克丁 (11.8%),局部艾弗梅克丁 (9.3%) 和 (10.8%) 观察到较低的失败率.
- 两剂口服艾弗梅克丁的失败率明显低 (7.1%),而不是单剂 (15.2%).
结论:
- 在治疗指导方针中,应考虑服用第二剂伊弗梅克丁.
- 随着时间的推移,越来越多的治疗失败表明潜在的虫易感性下降.
- 未来的研究应该评估杀剂的敏感性,并探索治疗失败的原因.
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