增长激素在体静止素神经中的作用 调节焦虑和恐惧 记忆力
Willian O Dos Santos1, Vitor A L Juliano2, Fernanda M Chaves1
1Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo 05508-000, Brazil.
概括
索马托斯坦神经元中的生长激素 (GH) 受体会影响焦虑和恐惧记忆. 这些神经元中的GH受体切除增加了男性的焦虑,并减少了两性恐惧记忆,揭示了神经精神疾病的关键途径.
科学领域:
- 神经内分泌学神经内分泌学
- 分子精神病学分子精神病学
- 行为神经科学 行为神经科学
背景情况:
- 增长激素 (GH) 失调与神经精神疾病 (如焦虑和PTSD) 有关.
- 杏仁体中的GH受体 (GHR) 信号影响恐惧记忆,这是PTSD的标志.
- 介导GH对大脑影响的特定神经元群体在很大程度上是未知的.
研究的目的:
- 为了确定大脑中GH作用的特定神经元点.
- 为了研究GHR信号传递在扩展桃体内的体静止素 (SST) 表达神经元中的作用.
- 阐明GHR废除在SST神经元对焦虑类行为和恐惧记忆的影响.
主要方法:
- 产生了表达SST的细胞特异性GHR淘汰小鼠 (SST).
- 使用光暗盒子和升高加迷宫测试来评估类似焦虑的行为.
- 通过听觉帕夫洛夫式恐惧调节和新型物体识别测试来评估恐惧记忆.
- 在中央和底侧杏仁体复合体中分析了基因表达.
主要成果:
- SSTΔGHR小鼠没有出现代谢变化,但在雄性中表现出增加的焦虑类行为.
- 雄性和雌性SSTΔGHR小鼠都显示出明显减少的恐惧记忆.
- 在SST神经元中的GHR切除导致了与桃体内突触可塑性相关的基因表达的性别依赖性变化.
结论:
- 在SST神经元中GHR信号传递对于调节雄性小鼠的焦虑至关重要.
- 在SST神经元中GHR信号传递对于两性正常的恐惧记忆巩固至关重要.
- 这项研究确定SST表达神经元作为一个关键的神经化学定义的人群,调解GH对神经精神疾病相关行为的影响.
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