通过社会代表和内化污名化来研究长期作用的阿片类药物替代治疗接受的预测因素
Aurélie Lacroix1, Victor Puybaret2, Pierre Villéger3
1Unité de recherche et d'innovation, centre hospitalier Esquirol, 87025 Limoges, France; Inserm U1094, EpiMaCT - Epidemiology of chronic diseases in tropical zone, Institute of Epidemiology and Tropical Neurology, OmegaHealth, CHU de Limoges, University Limoges, 87000 Limoges, France.
概括
针对阿片类药物使用障碍的一种新的注射性布普伦诺芬治疗方法显示出有前途,有54%的患者接受了它. 接受与对药物注射原因的信念有关,而不是内化污名.
科学领域:
- 成 药物 药物 药物 药物
- 公共卫生 公共卫生
- 精神病学是一个精神病学.
背景情况:
- 阿片类药物使用障碍 (OUD) 构成了全球公共卫生挑战,因耻辱和有限的治疗选择而加剧.
- 社会文化因素和耻辱因素导致OUD管理中的治疗差距显著.
- 在法国引入皮下注射 (SC) 布普伦诺芬溶液提供了一种新的治疗途径.
研究的目的:
- 调查在法国实施SC布普伦诺芬的潜在障碍.
- 确定预测患者接受一种新的SC注射形式的阿片类替代疗法 (OST) 的因素.
主要方法:
- 一项比较研究评估了OST患者的社会代表性 (使用EMIC) 和内化耻辱感 (使用ISMI).
- 患者根据他们接受新SC OST表格的可能性进行了分类.
- 此外,还研究了对阿片类戒断综合征的恐惧对治疗选择的影响.
主要成果:
- 包括50名OST患者中的54%接受了新的SC OST.
- 药物注射 (EMIC) 的较低感知原因与不接受有关.
- 两组之间没有发现内化耻辱 (ISMI) 的显著差异.
- 对戒断的恐惧在统计学上没有影响长期作用的SC OST的接受.
- 通过注射药物的感知原因,严重的DSM-5诊断和较低的酒精消费,最好预测患者的接受.
结论:
- 在接受和不接受SC OST的患者之间,在社会表现方面存在显著差异,但不是内化耻辱.
- 对于SC OST接受的预测因素是多因素的,涉及社会代表和临床特征.
- 需要对更大的队列进行进一步的前性研究,以验证这些研究结果对高剂量,长效布普伦诺芬输送的有效性.
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