已经够了:对专门代谢的反控制
Ying Li1, Erich Grotewold2, Natalia Dudareva3
1Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA; Purdue Center for Plant Biology, Purdue University, West Lafayette, IN 47907, USA.
Trends in plant science
|August 25, 2023
概括
植物使用小分子来控制代谢途径中的基因表达. 了解这些反机制是工程工厂生产有价值化合物的关键.
科学领域:
- 植物新陈代谢 植物新陈代谢
- 分子生物学分子生物学
- 生物化学 生物化学
背景情况:
- 专门的代谢物在调节植物生物合成网络中的基因表达中起着至关重要的作用.
- 小分子作为影响新陈代谢途径的信号.
研究的目的:
- 在植物的转录水平上审查小分子中介反调节的分子机制.
- 探索潜在的作用模式,包括信号感知,传感器识别和信号传输.
- 讨论研究小分子-蛋白相互作用的挑战.
主要方法:
- 文献审查和综合植物和其他生命形式的现有证据.
- 对控制转录和转录后调节的分子机制的分析.
- 讨论识别小分子-蛋白相互作用的挑战.
主要成果:
- 小分子可以通过各种传感和信号通路直接或间接地影响基因表达.
- 了解这些反循环对于破译代谢控制至关重要.
- 确定特定的小分子-蛋白相互作用仍然是一个重大挑战.
结论:
- 阐明小分子控制的代谢流程对于推进代谢工程至关重要.
- 转录调节系统的合理设计可以增强高价值的专门代谢物的产生.
- 对这些监管机制的进一步研究将打开新的生物技术应用.
相关概念视频
Regulation of Metabolism
9.5K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.5K
Introduction to Metabolism
84
Metabolism encompasses all biochemical reactions in a living organism, facilitating both the breakdown and synthesis of biomolecules. These metabolic processes are categorized into catabolic and anabolic pathways, which operate in a coordinated manner to ensure energy balance and cellular function.Catabolic Pathways and Energy ReleaseCatabolic pathways involve the breakdown of complex macromolecules such as carbohydrates, lipids, and proteins into smaller structures like monosaccharides, fatty...
84
Feedback Inhibition
54.0K
Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
54.0K
Metabolism of Chemolithotrophs
40
Chemolithotrophs are microorganisms that obtain energy by oxidizing inorganic molecules such as hydrogen gas (H₂), ammonia (NH₃), reduced sulfur compounds (H₂S, S²⁻), and ferrous iron (Fe²⁺). Unlike heterotrophic organisms that rely on organic carbon, chemolithotrophs transfer electrons from these inorganic donors to the electron transport chain (ETC), generating a proton motive force (PMF) that drives ATP synthesis through oxidative phosphorylation.
40
Positive and Negative Feedback Loops
19.4K
Animal organs and organ systems constantly adjust to internal and external changes through a process called homeostasis ("steady state"). Examples of these changes include regulation of the level of glucose or calcium in the blood or internal responses to external temperatures. Homeostasis requires maintaining an internal dynamic equilibrium:
19.4K
Overview of Metabolism
31.0K
Living cells constantly carry out various chemical reactions which are necessary for their proper functioning. These reactions are interlinked to one another via multiple pathways. The collection of these chemical reactions is known as metabolism.
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
Plant Metabolism
Sunlight, the primary source of energy in plants, is first absorbed by the chlorophyll pigments present in their leaves. Plants then use this energy to carry out photosynthesis, where water is oxidized into oxygen and carbon dioxide...
31.0K


