在偶发性偏头痛患者中进行头横直流刺激:对大脑输液的影响
Heiko Pohl1, Peter S Sandor1,2, Marius Moisa3
1Department of Neurology, University Hospital Zurich, Zurich, Switzerland.
Scientific reports
|August 25, 2023
概括
在偶发性偏头痛患者中,经直流刺激 (tDCS) 暂时增加了大脑血流. 这种增强的大脑输液,特别是在视觉处理区域,可能会暂时减少偏头痛的频率.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 脑血流模式在偏头痛患者和健康个体之间有所不同.
- 插曲性偏头痛与改变的大脑输液有关.
- 跨直流刺激 (tDCS) 正在研究偏头痛治疗.
研究的目的:
- 为了比较发作性偏头痛患者和健康对照者的脑输液.
- 为了研究阴道tDCS在脑后皮层对偏头痛患者大脑输液的影响.
- 评估tDCS对大脑血流的长期影响.
主要方法:
- 用MRI扫描来测量健康对照组和偶发性偏头痛患者的脑输液.
- 偏头痛患者每天在叶上接受活跃或假阳极tDCS,持续28天.
- 大脑输液在基线时被评估,刺激后不久,五个月后.
主要成果:
- 在偏头痛患者和对照人群之间,基线输液有所不同,偏头痛患者的皮质输液较低.
- 活性阳极tDCS在刺激后不久增加了视觉处理区域的血液流动.
- 这些输液变化在五个月的随访中并不显著.
结论:
- 偏头痛患者在骨中表现出较低的基线输液,这表明皮质预激活减少.
- 阴道tDCS在脑后皮层上可以暂时增加大脑血液流动.
- 输液的这种暂时增加可能是偏头痛频率观察到的减少的基础.
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