非常低出生体重的婴儿的神经发育特征不同
Reina Ogata1, Kyoko Watanabe2, Pin Fee Chong3
1Department of Pediatrics, National Hospital Organization Kokura Medical Center, Kitakyushu, 802-8533, Japan.
Pediatric research
|August 25, 2023
概括
非常低出生体重婴儿 (VLBWIs) 呈现出多样化的神经发育轨迹,直到6岁. 纵向跟踪揭示了自闭症谱系障碍/注意力缺陷多动症障碍与大脑麻在VLBWI的不同风险因素.
科学领域:
- 新生儿医学 新生儿医学
- 发育儿科 发育儿科
- 神经科学是一个神经科学.
背景情况:
- 先进的产周护理改善了早产婴儿的存活率.
- 非常低出生体重婴儿 (VLBWI) 的长期神经发育结果需要进一步调查.
研究的目的:
- 分析VLBWIs从3岁到6岁的神经发育轨迹.
- 确定围产期因素,神经发育结果和神经相关疾病之间的关联.
主要方法:
- 研究了一组124名在2007年至2015年间出生的VLBWI.
- 收集的数据包括围产期信息,3岁和6岁的发育/智力系数 (DQ/IQ) 和神经相关疾病.
- 神经成像 (MRI) 用于评估参与者的子集中的大脑病变.
主要成果:
- 在58名评估的VLBWIs中,15名 (26%) 在6岁时的DQ/IQ<75岁.
- 在3至6岁之间,36%的人显示DQ/IQ下降 (≤-10),而9%的人显示增加 (≥+10).
- 患有自闭症谱系障碍/注意力缺陷多动症障碍 (ASD/ADHD) 的VLBWIs显示出多样化的DQ/IQ变化,而脑患者的DQ得分明显较低.
结论:
- 在6岁时,VLBWIs表现出广泛的神经发育结果.
- 与VLBWIs中脑和相比,明显的围产期风险有助于ASD/ADHD的发展.
- 围产期大脑损伤与发育迟缓,脑和有关,但不是特别与6岁的ASD或ADHD有关.
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