在人类癌症中,含有12的通道四重化域的泛癌症分析
Pan Liu1, Zhilan Liu2, Qiankun Luo1
1Department of Hepato-Biliary-Pancreatic Surgery, Zhengzhou University People's Hospital (Henan Provincial People's Hospital), No. 7 Weiwu Road, Jinshui District, Zhengzhou, 450000, China.
Scientific reports
|August 25, 2023
概括
含有12 (KCTD12) 基因的通道四重化域在大多数癌症中是下调的,并且与预后不佳有关. KCTD12的表达会影响瘤免疫力和干性,因此具有作为泛癌诊断和预后标记物的潜力.
科学领域:
- 在瘤学瘤学.
- 基因组学就是基因组学.
- 免疫学 免疫学 免疫学
背景情况:
- 含有12 (KCTD12) 表达的异常通道四重化域与各种癌症有关.
- 缺乏对KCTD12作用的全面泛癌分析.
研究的目的:
- 研究KCTD12与30多种人类恶性瘤之间的关联.
- 评估KCTD12作为癌症诊断,预后和免疫透的潜在生物标志物.
主要方法:
- 利用癌症基因组图集 (TCGA) 和基因表达总汇 (GEO) 数据库进行分析.
- 检查了KCTD12mRNA和蛋白质水平,将它们与瘤特征和患者存活率相关联.
- 分析了免疫细胞透 (CD8+,CD4+T细胞),与癌症相关的纤维细胞,瘤干性和基因组异质性.
- 进行KEGG/GO通路分析以探索分子机制.
主要成果:
- 在大多数分析的瘤中,KCTD12 mRNA和蛋白质水平下降,与患者预后较差相关.
- 在某些癌症,如胰腺腺癌 (PAAD),肺腺癌 (LUAD) 和乳腺侵入性癌 (BRCA) 中观察到KCTD12酸化的降低.
- 在几种癌症 (CESC,HNSC,PAAD,STAD) 中,KCTD12表达与与癌症相关的纤维细胞透正相关,并影响了T细胞透.
- KCTD12显示出高的诊断灵敏度和潜在的参与瘤细胞干细胞和负担.
结论:
- KCTD12 作为一个重要的泛癌生物标志物用于诊断和预后.
- KCTD12表达与免疫细胞透和瘤生物特征有关.
- 进一步研究KCTD12的分子功能和途径是有必要的.
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