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Updated: Jul 18, 2025

Hyperinsulinemic-euglycemic Clamps in Conscious, Unrestrained Mice
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O304通过双重促进肌肉葡萄糖的有效性和保持β细胞功能来改善小鼠的高血糖症

Stefan Norlin1, Jan Axelsson2, Madelene Ericsson1

  • 1Umeå Centre for Molecular Medicine, Umeå University, SE-901 87, Umeå, Sweden.

Communications biology
|August 25, 2023
PubMed
概括

AMPK激活剂O304增强胰岛素独立的葡萄糖吸收和利用在骨肌肉和心脏. 这种化合物还保留了胰腺β细胞的功能,解决了2型糖尿病的关键缺陷.

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Dipeptidyl peptidase 4 (DPP-4) is a serine protease widely distributed in the body. It's involved in the inactivation of GLP-1 and GIP hormones, which are crucial for insulin regulation. DPP-4 inhibitors, such as sitagliptin (Januvia), saxagliptin (Onglyza), linagliptin (Tradjenta), alogliptin (Nesina), and vildagliptin (Galvus), help increase the proportion of active GLP-1, enhancing insulin secretion. These inhibitors work by competitively binding to DPP-4. This binding causes a...
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α-glucosidase inhibitors, including acarbose (Precose), miglitol (Glyset), and voglibose (Voglib) (primarily available in Asia), are drugs that control blood sugar levels by delaying the digestion of starch and disaccharides. They achieve this by inhibiting α-glucosidase enzymes in the intestine, which slow the absorption of carbohydrates in the intestine, which in turn leads to a prolonged release of the glucoregulatory hormone GLP-1 from intestinal L-cells.
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