在血造细胞移植患者中评估静脉血栓塞栓症预防方案
Angela Lee1, Corinne Badgley2, Mimi Lo2
1Department of Clinical Pharmacy, University of California, San Francisco, San Francisco, CA, USA. Angela.Lee4@ucsf.edu.
Bone marrow transplantation
|August 25, 2023
概括
接受静脉血栓栓塞 (VTE) 预防的血造细胞移植 (HCT) 患者没有增加出血风险. 这项研究表明VTE预防对HCT接受者来说是安全的,趋势是VTE事件减少.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学 移植医学
- 血栓形成和血液静止.
背景情况:
- 血造细胞移植 (HCT) 接受者面临高血栓栓塞和出血并发症的高风险.
- 在住院高血栓塞栓症患者的静脉血栓塞栓症 (VTE) 预防的最佳管理仍然不清楚.
研究的目的:
- 评估住院高血压瘤患者静脉瘤预防的安全性和有效性.
- 为了比较接受预防和历史对照的患者之间的出血和VTE事件率.
主要方法:
- 对614名HCT患者进行了回顾性队列研究.
- 根据使用埃诺沙巴林或肝素的VTE预防协议 (VPP) 管理的患者与没有预防的历史对照进行比较.
- 主要结局:主要,临床相关的非主要和轻微出血事件的组合.
- 二次结果:VTE事件的组合.
主要成果:
- 静脉瘤预防没有显著增加出血事件 (14.6%的VPP后与15.1%的VPP前,p=0.86).
- 主要和临床相关的非重大出血事件的发生率在两组之间相似 (0.30%与0.72%,p=0.59).
- 在VPP后的组中观察到VTE事件发生率较低的趋势 (6.0%对8.6%,p=0.20).
结论:
- 静脉血栓塞栓症预防在血液细胞移植患者中是安全的,因为它不会增加出血风险.
- 实施的VTE预防方案显示,在HCT接受者中减少VTE事件的趋势并不显著.
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