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美国暴露与人体成分之间的关联:基于人口的横截面研究
Xingyang Su1, Zilong Zhang1, Shi Qiu1
1Department of Urology and Institute of Urology, West China Hospital, Sichuan University, Chengdu, 610041, China.
BMC public health
|August 25, 2023
概括
尿中的含量显示了成年人与身体组成的剂量反应关系. 低水平的暴露与体重和BMI增加有关,但肌肉质量和骨质量下降.
科学领域:
- 环境健康 环境健康
- 人体生理学 人体生理学
- 毒理学 毒理学 毒理学
背景情况:
- 身体组成的变化,如体脂增加或肌肉和骨质量减少,与成年人的不良健康结果有关.
- 尼克尔暴露对身体成分的影响仍然在很大程度上不明.
- 这项研究调查了尿液含量与身体组成参数之间的关联.
研究的目的:
- 为了检查尿液中含量与成人各种体质成分指标之间的关系.
- 为了确定暴露对身体组成的潜在剂量反应关系和和效应.
主要方法:
- 分析了2017-2018年国家健康和营养检查调查的2,762名参与者的数据.
- 利用加权通用线性模型,灵敏度分析和子组分析来评估关系.
- 采用曲线拟合和和效应分析来探索尿和身体成分之间的非线性关联.
主要成果:
- 没有发现尿和身体成分之间有显著的线性关系.
- 观察到和效应,不同的身体组成指标具有特定的转折点.
- 在这些转折点以下,增加的尿与更高的体重和BMI有关,以及较低的总瘦质 (TLM),尾瘦质 (ALM) 和骨矿物质含量 (BMC).
- 尿也与增加的体脂肪量 (TRF) 和总体脂肪量 (TOF) 有关.
结论:
- 尿中含量和身体成分之间存在剂量反应关系.
- 该研究确定了对身体组成的和效应的低拐点.
- 这些发现表明,即使是低水平的暴露也可能影响成年人的身体组成.
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