戈西波 (Gossypol) 通过调节素乙化调节,改善因败血症引起的心肌功能障碍
Xiaohui Shi1, Xinwei Lv1, Dong Xiao1
1Department of Critical Care Medicine, People's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang, China.
Clinical and translational science
|August 26, 2023
概括
棉花植物聚醇Gossypol通过减少炎症和氧化应激来治疗败血症,显示出有前途. 这项研究表明gossypol.
科学领域:
- 生物化学 生化学
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
背景情况:
- 败血症是一种危及生命的炎症性疾病.
- 炎症,氧化应激和表观遗传变化有助于败血症病理.
- 戈西波尔表现出抗炎,抗氧化和素脱乙酶 (HDAC) 抑制性质.
研究的目的:
- 评估gossypol在败血症小鼠模型中的治疗潜力.
- 调查戈西波尔对心肌损伤和败血症中氧化应激的影响.
- 检查gossypol对炎症途径和毒症表观遗传修饰的影响.
主要方法:
- 一个结刺 (CLP) 鼠标模型被用于诱导败血症.
- 戈西波 (Gossypol) 用于CLP小鼠和用脂聚糖化物 (LPS) 治疗的心肌细胞.
- 测量包括生存率,心肌损伤和氧化标志物,促炎性细胞因子,AKT/IKK激活,基因素乙化和HDAC表达.
主要成果:
- 戈西波治疗改善了CLP小鼠的存活率,并减少了心肌损伤.
- 戈西波尔降低了氧化应激标志物,并增加了败血症小鼠的抗氧化剂生产.
- 戈西波尔抑制了促炎性细胞因子的产生,抑制了AKT和IKK的激活,并降低了LPS治疗细胞中的基因组乙化和HDAC表达.
结论:
- 戈西波尔证明了对败血症诱导的心肌功能障碍的保护作用.
- 戈西波尔通过调节关键信号通路和表观遗传因素来缓解症中的炎症和氧化应激.
- 戈西波尔代表了治疗毒症并发症的潜在治疗剂.
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