催产素与精神分裂患者的依恋的相互作用:一项fMRI研究
Kristina Hennig-Fast1,2, Dominik Meissner1, Carolin Steuwe2
1Department of Psychiatry and Psychotherapy, Ludwig-Maximilians University, 80336 Munich, Germany.
Brain sciences
|August 26, 2023
概括
精神分裂症患者表现出不安全的依恋和较低的催产素 (OXT) 水平. 脑部成像显示了精神分裂症患者在特定脑部区域的自我相关区域的神经激活变化和OXT调制.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 心理学 心理学 心理学
背景情况:
- 附件理论为理解人际互动提供了一个框架.
- 精神分裂症与改变的社会认知和情绪处理有关.
- 催产素在社会结合中起作用,可能与精神疾病有关.
研究的目的:
- 研究与健康对照组 (HC) 相比,男性精神分裂症患者 (SZP) 的依恋模式和催产素水平的神经相关性.
- 检查SZP和HC之间的附着方式和催产素水平的差异.
- 探索神经激活,附着和SZP中的催产素之间的关系.
主要方法:
- 使用功能性磁共振成像 (fMRI) 以与事件相关的设计.
- 使用来自成人依恋投影图像系统的刺激来评估依恋表现.
- 在依恋模式,催产素水平和大脑活动方面,比较了20个男性SZP和20个男性HC.
主要成果:
- 与HC相比,在SZP中证实了较高比例的不安全连接.
- 发现SZP的催产素水平明显低于HC.
- 在依附相关任务期间,观察到SZP在前,关节 (TPJ),胰岛和额头部区域的增加大脑激活.
- 在SZP中,确定了催产素与双边脊侧前额皮层 (dlPFC),前皮层和左前环皮层 (ACC) 之间的正相关性.
结论:
- 在处理个性化,与依恋相关的材料时,SZP可能会表现出失调.
- 催产素可以调节神经网络中的神经活动,包括dlPFC,precuneus和SZP中的ACC.
- 研究结果表明,催产素在精神分裂症中依恋的神经支柱中可能发挥作用.
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