吸烟状态中的性别差异及其与大脑体积的关联使用大规模社区代表性数据
Xiaofei Chen1, Riley Cook2, Francesca M Filbey3
1Department of Statistics and Data Science, Southern Methodist University, Dallas, TX 75205, USA.
Brain sciences
|August 26, 2023
概括
吸烟会影响大脑结构,过去的吸烟者会出现灰质损失. 这项研究揭示了这些与吸烟相关的大脑变化中的显著性别差异,特别是在男性中.
科学领域:
- 神经科学是一个神经科学.
- 神经成像是一种神经成像.
- 公共卫生 公共卫生
背景情况:
- 吸烟与加速与年龄相关的神经退行有关.
- 现有研究表明,吸烟相关的大脑结构变化中性别差异存在不一致.
研究的目的:
- 调查吸烟者皮下灰质体积和侧腔室变化的性别特异性差异.
- 为了比较活跃,过去和从未吸烟者的大脑结构,按性别分层.
主要方法:
- 1959年达拉斯心脏研究 (DHS) 参与者的脑部成像数据的分析.
- 按性别分层,在三个吸烟组 (活跃,过去,从未) 进行了多组比较.
- 在特定的皮下区域和侧腔室中检查了灰质体积.
主要成果:
- 前吸烟者表现出最显著的皮下灰色物质体积损失和侧腔室扩大在两性.
- 这些体积变化在调整年龄和内体积后,仅在男性中具有统计学意义.
- 表明终身吸烟对大脑结构的潜在性别特异性影响.
结论:
- 终身吸烟与灰色物质体积变化有关.
- 与吸烟相关的灰质体积变化存在显著的性别差异,即使考虑到衰老和内体积.
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