边缘性人格障碍患者的自闭症和白内障频谱症状
Liliana Dell'Osso1, Giulia Amatori1, Ivan Mirko Cremone1
1Department of Clinical and Experimental Medicine, University of Pisa, 56126 Pisa, Italy.
Brain sciences
|August 26, 2023
概括
边缘性人格障碍 (BPD) 和严重抑郁障碍 (MDD) 的患者表现出比对照人群更高的卡塔托尼和自闭症特征 (AT). 特定的特征预测BPD风险,表明精神障碍进展的联系.
科学领域:
- 精神病学是一个精神病学.
- 临床心理学 临床心理学
- 神经科学是一个神经科学.
背景情况:
- 严重的精神障碍可能会发展为猫,自闭症特征 (AT) 和边缘性人格障碍 (BPD) 可能会先于它.
- 了解AT,BPD和catatonia之间的关系对于识别疾病轨迹至关重要.
- 之前的研究表明,精神障碍的严重程度是连续的,导致了catatonia.
研究的目的:
- 在患有主要抑郁症 (MDD),边缘性人格障碍 (BPD) 和健康对照组 (CTL) 的患者中,比较卡塔顿谱症状和自闭症特征 (AT).
- 确定这些群体内的不同诊断的潜在预测维度.
- 为了探索AT,BPD和catatonia之间的关联.
主要方法:
- 招募了90名患有BPD的成年人,90名患有MDD和90名健康对照 (CTL).
- 参与者根据性别和年龄在不同群体中进行了匹配.
- 评估包括对DSM-5-TR (SCID-5-RV),Catatonia Spectrum (CS) 和成人自闭症下值自闭症谱 (AdAS谱) 问卷的结构化临床面试.
主要成果:
- 无论是BPD和MDD组,总的CS分数都明显高于CTL组.
- BPD组的CS域得分高于MDD组,而MDD组的CS域得分也高于CTL组.
- 与MDD和CTL组相比,BPD组的总AdAS频谱得分和域得分也明显高于MDD和CTL组,MDD得分高于CTL.
- 特定的CS领域 (精神运动活动,冲动性) 和AdAS频谱领域 (口头沟通,同情,感官反应) 与BPD风险有关.
结论:
- 与健康个体相比,患有BPD和MDD的患者表现出较高水平的触觉和自闭症特征.
- 自闭症特征和特定的触觉症状与BPD的风险增加有关.
- 这些发现支持了疾病连续的模型,其中自闭症特征和猫色症可能与严重精神障碍的进展有关.
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