脑源性神经营养因子可以被认为是双相情感障碍的生物标志物吗? 对当前证据的分析
Gianmarco De Felice1, Mario Luciano1, Alessia Boiano1
1Department of Psychiatry, University of Campania Luigi Vanvitelli, 80138 Naples, Italy.
Brain sciences
|August 26, 2023
概括
大脑衍生神经营养因子 (BDNF) 可能作为双相情感障碍 (BD) 的生物标志物. 在BD急性阶段较低的BDNF水平表明其在疾病和恢复中的潜在作用.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
背景情况:
- 大脑衍生神经营养因子 (BDNF) 对于神经元的生存和神经可塑性至关重要.
- BDNF与各种神经和精神疾病有关.
研究的目的:
- 对双相情感障碍 (BD) 中BDNF的现有数据进行审查.
- 评估BDNF作为BD的潜在生物标志物.
主要方法:
- 在医疗数据库中系统地搜索BDNF水平和BD患者和健康对照 (HC) 患者的Val66Met多态性研究.
- 包括29项比较BD患者与HC患者的研究,使用国际标准诊断.
主要成果:
- 与HC相比,在BD急性阶段观察到的BDNF循环水平降低.
- 在有效的BD治疗后,BDNF水平增加.
- 该BDNF Val66Met多态性与较差的临床结果相关.
结论:
- 作为双相情感障碍的生物标志物,BDNF显示出前景.
- 由于研究中观察到的异质性,需要进一步的研究.
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