脂肪性肝病:代谢功能障碍,酒精,还是两者兼而有之?
Katharina Staufer1, Rudolf E Stauber2
1Division of Transplantation, Department of General Surgery, Medical University of Vienna, 1090 Vienna, Austria.
Biomedicines
|August 26, 2023
概括
脂肪性肝病 (SLD),包括与代谢功能障碍相关的脂肪性肝病 (MASLD) 和与酒精有关的肝病 (ALD),由于重叠的症状,存在诊断挑战. 了解它们的共同点对于改善临床护理和研究至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 胃肠病学 胃肠病学
- 公共卫生 公共卫生
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 和与酒精有关的肝病 (ALD) 是全球慢性肝病的主要原因.
- 这两种情况,现在在术语脂肪性肝病 (SLD) 下,具有临床相似之处,但在预后和治疗方面有所不同.
- NAFLD正在迅速增加,而ALD的患病率保持稳定,使早期诊断复杂化.
研究的目的:
- 审查目前关于NAFLD/MASLD和ALD之间的共同点的知识.
- 确定了解脂肪性肝病 (SLD) 的临床和研究差距.
- 强调需要改善SLD的诊断策略.
主要方法:
- 对NAFLD,ALD和SLD现有研究的文献综述.
- 对临床表现,预后和治疗方法的分析.
- 综合关于共同特征和差异的信息.
主要成果:
- NAFLD/MASLD和ALD表现出重叠的临床特征,使得区分变得困难.
- 引入SLD的目的是减少与脂肪肝疾病相关的耻辱.
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 和ALD存在于一个频谱上,包括MetALD.
结论:
- 准确和早期诊断SLD是必不可少的,但具有挑战性.
- 需要进一步的研究来阐明MASLD和ALD的共同点和独特方面.
- 对SLD的统一理解对于推进患者护理和公共卫生战略至关重要.
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