严重的COVID-19患者的肥胖症具有明显的先天免疫表型
Ayane de Sá Resende1, Yrna Lorena Matos de Oliveira1, Mariana Nobre Farias de Franca1
1Health Sciences Graduate Program, Federal University of Sergipe, Aracaju 49060-100, Sergipe, Brazil.
Biomedicines
|August 26, 2023
概括
肥胖症通过改变白细胞功能,在严重的COVID-19中显著损害了先天免疫反应. 肥胖患者显示单细胞减少和中性粒细胞改变,影响免疫细胞相互作用和疾病严重程度.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 众所周知,肥胖会在感染期间损害免疫反应.
- 肥胖对严重COVID-19免疫细胞表型的特定影响需要进一步阐明.
研究的目的:
- 为了研究严重的COVID-19患者肥胖的白细胞的免疫类型变化.
- 将这些变化与临床和生化参数相关联.
主要方法:
- 对27名ICU COVID-19患者的横截面研究,分为肥胖 (BMI ≥30 kg/m2) 和非肥胖的组.
- 单细胞,自然杀手 (NK) 细胞,低密度 (LD) 和高密度 (HD) 中性粒细胞的流细胞计分析.
- 评估表面受体表达,临床状态和生物化学数据.
主要成果:
- 肥胖与单细胞的频率降低有关,这些单细胞表现出高水平的PD-L1.
- 在肥胖患者中观察到NK细胞的频率增加和TREM-1在HD中性粒细胞上的更高表达.
- 免疫受体表达与仅在肥胖个体中的临床标志物有很强的相关性,这表明先天免疫反应失调.
结论:
- 肥胖会显著改变先天免疫细胞的数量和功能,在严重的COVID-19中.
- 白细胞中的这些免疫表型变化可能导致肥胖COVID-19患者观察到的较差结果.
- 针对这些由肥胖引起的免疫失调可能对管理严重的COVID-19至关重要.
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