相关实验视频

Updated: Jul 18, 2025

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation

Published on: October 25, 2024

结核病和COVID-19双重影响人类Th17细胞免疫反应

Anna Starshinova¹, Igor Kudryavtsev², Artem Rubinstein²

¹Almazov National Medical Research Centre, 197341 St-Petersburg, Russia.

|August 26, 2023

概括

COVID-19显著改变了结核病患者的免疫反应,影响了疾病的过程和严重程度. 了解这些变化对于管理潜在结核病感染和活跃结核病,特别是SARS-CoV-2感染后的管理至关重要.

科学领域:

免疫学免疫学免疫学
传染性疾病传染性疾病
肺部病理学肺部病理学

背景情况:

COVID-19影响结核病 (TB) 检测和免疫反应.
免疫反应的改变对于了解结核病的发展和进展至关重要,特别是在同时感染的患者中.
研究潜伏结核病感染 (LTBI) 和SARS-CoV-2感染结核病患者的免疫变化至关重要.

研究的目的:

审查结核病患者和康复期的COVID-19患者的免疫反应特征.
分析SARS-CoV-2感染如何影响与结核相关的免疫格局.

主要方法:

从2019年12月到2023年3月的出版物的系统文献综述.
使用关键字搜索了主要数据库 (Medline,PubMed,Scopus):COVID-19,SARS-CoV-2,结核病,肺结核病,LTBI,Treg,毛囊Treg,Treg子集.使用关键字搜索了主要数据库 (Medline,PubMed,Scopus).
分析了结核病和COVID-19患者的免疫反应特征.

主要成果:

以前患有COVID-19的结核病患者显示Th1和Th2细胞水平升高,表明免疫反应被激活.
COVID-19或COVID-19后的受试者表现出降低的Th17水平,可能限制结核病的发展.
虽然结核病通常会增加Treg水平,但COVID-19可以诱导高炎症反应,与典型的Treg相关免疫调节形成鲜明对比.

结论:

SARS-CoV-2 感染通过修改的免疫反应明显改变了结核病的进展.
调控性T细胞 (Treg) 水平的下降与严重活跃结核病的发展有关.
这两种病原体都会破坏免疫平衡,增加严重结核病的风险,并需要改善潜伏和活跃结核病患者的管理策略.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.这就是Treg Treg.这是Treg子集的子集.这是自身免疫力.冠状病毒感染冠状病毒感染毛囊细胞Treg是什么意思潜伏的结核病感染.肺结核 - 肺结核结核病是一种肺结核病.

更多相关视频

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes

Published on: September 26, 2013

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Author Spotlight: Advancing Immune Monitoring in Critical Care Patients Using Whole Blood Assays

Published on: September 20, 2024

相关概念视频

Pulmonary Tuberculosis I

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

T Cell Types and Functions

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

Pulmonary Tuberculosis II

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...

Pulmonary Tuberculosis V

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...

Pulmonary Tuberculosis IV

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...

Pulmonary Tuberculosis III

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories: