神经性下尿路症状,疲劳和抑郁 - - 多发性硬化症患者之间是否存在相关性?
Anke K Jaekel1,2, Julius Watzek1, Jörn Nielsen3,4
1Department of Neuro-Urology, Clinic for Urology, University Hospital Bonn, 53127 Bonn, Germany.
Biomedicines
|August 26, 2023
概括
多发性硬化症 (MS) 中的疲劳和抑郁症与神经性下尿路症状 (LUTS) 有关. 紧迫性和减少空气体积显著影响MS患者的疲劳和抑郁症严重程度.
科学领域:
- 神经学 神经学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 精神病学是一个精神病学.
背景情况:
- 多发性硬化症 (MS) 通常表现为疲劳,抑郁和神经性下尿路症状 (LUTS).
- 在MS患者中,特定的LUTS与疲劳和抑郁症的严重程度之间的相互作用仍未得到充分研究.
- 了解这些关系对于全面的患者护理至关重要.
研究的目的:
- 调查各种神经源性LUTS与MS患者的疲劳和抑郁程度之间的联系.
- 为了确定哪些特定的LUTS对疲劳和抑郁有最显著的影响.
主要方法:
- 分析了274名多发性硬化患者的膀日记数据.
- 使用运动和认知功能的疲劳量表来评估疲劳.
- 使用流行病学研究中心抑郁症尺度 (德语版) 评估抑郁症.
- 神经性LUTS的定义包括紧迫性,减少排泄量,增加排泄频率,夜尿和尿失禁.
主要成果:
- 患有尿失禁,夜尿症,空气体积减少或紧急情况的患者报告疲劳得分更高.
- 夜与较高的抑郁症得分有显著的关联.
- 紧急情况的严重程度和空气流量减少与疲劳和抑郁水平的相关性最强.
- 增加的紧迫性预测了临床上显著的疲劳和抑郁症的风险更高.
结论:
- 特定的神经源性LUTS,特别是紧迫性和减少空气体积,与MS患者疲劳和抑郁症的增加有显著的关联.
- 这些发现凸显了考虑和管理LUTS的必要性,以改善MS患者的心理和功能福祉.
- 建议进行进一步的纵向研究,以确定因果关系,并探索与LUTS相关的疲劳和抑郁症的治疗策略.
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