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检查运动,肠道微生物群和神经退行之间的相互作用:未来研究方向

Daniel Rojas-Valverde^1,2, Diego A Bonilla^3,4,5,6, Luis M Gómez-Miranda⁷

¹Nucleus of Studies for High Performance and Health (CIDISAD-NARS), School of Human Movement Sciences and Quality of Life (CIEMHCAVI), National University, Heredia 86-3000, Costa Rica.

|August 26, 2023

概括

定期体育活动和健康的肠道微生物群显著影响大脑健康. 运动和肠道微生物影响神经退行,为神经系统疾病提供潜在的治疗途径.

科学领域:

神经科学是一个神经科学.
微生物学微生物学
运动科学运动科学

背景情况:

肠-大脑轴,包括肠道微生物群和身体活动,对神经健康至关重要.
肠道微生物多样性和功能的变化与神经退行性疾病的发病和进展有关.
新兴研究强调了运动,微生物群和神经退行之间的复杂相互作用.

研究的目的:

审查关于肠道,体育炼,微生物群和神经退行之间的联系的当前文献.
总结运动和肠道微生物群在神经退行症中的作用.
确定影响神经疾病的相互连接途径.

主要方法:

对PubMed/MEDLINE,Web of Science和谷歌学者数据库的系统文献审查.
搜索进行到2023年6月1日.
综合了有关运动,肠道微生物群和神经退行症的发现.

主要成果:

身体活动对肠道微生物的多样性和功能有积极的影响.
肠道微生物群在神经退行性疾病期间的代谢转变中发挥着至关重要的作用.
运动诱导神经化学变化 (例如,内啡,血清) 与改善大脑健康和认知功能有关.

结论:

由运动和微生物群调节的肠-大脑轴是神经退行的一个关键因素.
运动和肠道微生物群调节在延迟或减轻神经系统疾病方面表现有前途.
需要进一步的临床研究来探索这些相互作用中的基于年龄和性别的差异.

关键词:

进行炼干预.肠大脑轴肠大脑轴免疫系统免疫系统这是一种炎症炎症炎症炎症.乳酸乳酸是一种乳酸.代谢功能的代谢功能微生物多样性的微生物多样性神经退行性疾病是一种神经退行性疾病.

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