皮肤和肠道微生物组在Hidradenitis Suppurativa:一个系统的审查
Edyta Lelonek1, Dorra Bouazzi2, Gregor B E Jemec2
1Department of Dermatology, Venereology and Allergology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Biomedicines
|August 26, 2023
概括
补腺炎 (HS) 是一种慢性皮肤疾病. 本综述考察了HS患者的皮肤和肠道微生物群的差异,发现了不一致性,并呼吁对微生物的作用和治疗进行先进的研究.
科学领域:
- 皮肤病学和微生物学
背景情况:
- 补腺炎 (HS) 是一种慢性炎症性皮肤疾病,影响生活质量.
- HS病理生理学涉及炎症,遗传学,微生物群和环境因素.
- 在HS病变发生过程中的肠-皮肤微生物相互作用尚未完全理解.
研究的目的:
- 系统地审查和分析HS患者和健康对照人群之间的皮肤和肠道微生物组合的差异.
- 确定与HS相关的微生物组研究当前的研究差距和方法限制.
主要方法:
- 对HS患者和对照者的皮肤和肠道微生物组进行比较的研究进行系统性文献综述.
- 对现有研究方法和研究结果的分析.
主要成果:
- 在当前的研究方法和有关HS微生物组组成的发现中发现了重大不一致性.
- 强调需要标准化和先进的研究方法.
结论:
- 需要进一步的研究来阐明微生物组在HS病变发生过程中的确切作用.
- 微生物组研究方法的进步 (metataxonomics,metagenomics) 对于理解HS和开发新型治疗干预措施至关重要.
相关概念视频
Anatomy of the Intestines
72.4K
Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...
72.4K
Assessment of the Gastrointestinal System I: Subjective Data
224
Assessing the gastrointestinal (GI) system is a complex process that begins with collecting subjective data. This data, collected through patient interviews, provides crucial insights into the patient's health history, perception patterns, and lifestyle habits, all contributing significantly to GI health.
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
Health History
The initial step in assessing the GI system is obtaining a comprehensive health history. This includes inquiring about the patient's history or presence of problems...
224
Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K
Accessory Structures of the Skin: Sebaceous Glands
2.0K
A sebaceous gland is a type of oil gland found almost all over the skin ( except palms and soles) and helps lubricate and waterproof the skin and hair. Most sebaceous glands are associated with hair follicles. They generate and excrete sebum, a mixture of lipids, onto the skin surface, thereby naturally lubricating the dry and dead layer of keratinized cells of the stratum corneum, keeping it pliable.
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
These glands that produce the oils on the skin and hair are holocrine glands. The mature...
2.0K


