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在儿童肥胖症中循环和外体微RNA-33

Manuela Cabiati¹, Letizia Guiducci¹, Emioli Randazzo²

¹Laboratory of Biochemistry and Molecular Biology, Institute of Clinical Physiology, CNR, 56124 Pisa, Italy.

|August 26, 2023

概括

循环中的microRNA-33a (miR-33a) 在肥胖青少年中升高,与代谢功能障碍相关. 这种生物标志物可以帮助识别患有较高心脏代谢风险的肥胖青年.

科学领域:

生物化学生物化学
分子生物学分子生物学
代谢研究研究代谢研究

背景情况:

微RNA-33 (miR-33) 在各种代谢功能中发挥作用.
了解miR-33a在青少年代谢健康中的作用至关重要.

研究的目的:

评估正常体重和肥胖青少年的循环miR-33a概况.
为了将miR-33a表达与代谢参数相关联.
为了比较循环和外体 miR-33a.

主要方法:

招募了20名体重正常的青少年和30名肥胖的青少年.
测量了循环和外体miR-33a水平.
与辅助学和代谢指数相关的miR-33a.

主要成果:

肥胖的青少年表现出改变的代谢参数和更高的循环miR-33a.
循环中的miR-33a与胰岛素,胆固醇,LDL和HbA1c显著相关.
循环中的miR-33a水平较高与肥胖和代谢功能障碍的增加有关,无论肥胖状况如何.

结论:

循环中的miR-33a是青少年代谢功能障碍的有价值的早期指标.
外体miR-33a没有提供额外的诊断价值.
循环中的miR-33a可以通过心脏代谢风险对肥胖青少年进行分层.

关键词:

实时PCR可以实现.童年的童年童年的童年这是一个微型RNA-33RNA.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖

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