孕前症和抗脂综合征
Karoline Mayer-Pickel1, Manurishi Nanda1, Maja Gajic1
1Department of Obstetrics, Medical University Graz, 8036 Graz, Austria.
怀孕期间的抗脂综合征 (APS) 会增加孕前和早产的风险. 氧化和维生素D作为标准护理之外的额外治疗方法具有前景.
科学领域:
- 产科和妇科 产科和妇科
- 免疫学 免疫学 免疫学
- 类风湿病学 类风湿病学
背景情况:
- 抗脂综合征 (APS) 涉及由于抗脂抗体 (aPLs) 的血栓和妊娠并发症.
- 早期发病的孕前 (<34周) 是APS的临床标准,与缺陷的 trofhoblast 侵袭共享病理生理学.
- 患有APS的女性面临着早产风险的增加,通常与胎盘功能障碍有关,如孕前或胎儿生长限制 (FGR).
研究的目的:
- 审查抗脂综合征 (APS) 与怀孕并发症之间的关联.
- 讨论当前和潜在的治疗策略在怀孕期间APS.
- 要突出氧化 (HCQ),维生素D和黄素在怀孕期间管理APS的作用.
主要方法:
- 关于抗脂综合征 (APS) 和怀孕结果的文献综述.
- 对病理生理学的分析,将APS和子宫前联系起来.
- 对孕妇APS的现有和新兴治疗方法的评估.
主要成果:
- 孕前症使10-17%的APS怀孕复杂化;早期发病是诊断标准.
- 患有APS的女性的早产率更高,即使没有孕前或FGR.
- 标准治疗 (阿司匹林,肝素) 对20-30%的患者来说是不够的,需要进一步的干预.
结论:
- 氧化 (HCQ) 是一种有效的额外治疗APS在怀孕期间.
- 像维生素D这样的营养干预措施有望改善结果.
- 黄素的抗氧化和抗炎性质表明,它有可能在怀孕期间作为APS的辅助疗法.
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