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多分子 (ADP-Ribose) 聚合酶-1缺乏酶活性与小鼠发育不兼容

Tatiana Kamaletdinova1, Wen Zong2, Pavel Urbánek1

  • 1Leibniz Institute on Aging-Fritz Lipmann Institute (FLI), 07745 Jena, Germany.

Cells
|August 26, 2023
PubMed
概括

不激活Poly ((ADP-ribose) 聚合酶-1 (PARP1) 酶活性会导致小鼠的胚胎死亡,而不是完全的PARP1淘汰. 这表明PARP1的催化功能对发育至关重要,可能涉及PARP2相互作用.

关键词:
ES细胞的分化 ES细胞的分化PARP1 的第一部分在PARP2中,PARP2是PARP2.催化活动的催化活动.发展发展发展发展发展.遗传毒性压力是一种遗传毒性压力.

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