缺少胆道癌症的免疫疗法生物标志物:全面的系统文献综述和元分析
Giorgio Frega1, Fernando P Cossio2, Jesus M Banales3,4,5
1Osteoncology, Soft Tissue and Bone Sarcomas, Innovative Therapy Unit, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.
Cells
|August 26, 2023
概括
免疫疗法在胆道癌症 (BTC) 中表现有前途. 这次审查发现,编程死亡连接体1 (PD-L1) 在约26%的BTC患者中表达,但仍然需要一个可靠的生物标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 生物标志物发现发现
背景情况:
- 免疫疗法是胆道癌症 (BTC) 的新疗法.
- 识别生物标志物来预测治疗反应对于患者选择至关重要.
- 这项研究审查了BTC中的免疫相关生物标志物.
结论:
- 在约26%的BTC患者中,PD-L1表达存在,不论其解剖位置如何.
- 在BTC中,TMB-H和MSI分子表型并不常见.
- 一个可靠的预测生物标志物,特别是对于不匹配的瘤,仍然缺乏,需要进一步的研究.
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