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胰岛素可以延迟中性粒细胞外细胞陷的形成在体外-用于糖尿病伤口护理的含义?

Caren Linnemann¹, Filiz Şahin¹, Ningna Li²

¹Siegfried Weller Institute for Trauma Research, BG Unfallklinik Tübingen, Eberhard Karls Universität Tuebingen, 72076 Tuebingen, Germany.

|August 26, 2023

概括

胰岛素可以调节中性粒细胞外细胞陷 (NETs) 的形成,这是糖尿病伤口愈合受损的关键因素. 这一发现表明胰岛素可能为治疗糖尿病并发症提供了一种新的治疗方法.

科学领域:

免疫学免疫学免疫学
内分泌学在内分泌学.
伤口治愈研究研究伤口治愈研究

背景情况:

糖尿病是一种全球性健康问题,其主要并发症是伤口愈合延迟.
中性细胞外细胞陷 (NETs) 在炎症反应中至关重要,但有助于糖尿病的愈合受损.
现有的抗糖尿病药物,如甲福明和利拉格卢提德,可以调节NET的形成.

研究的目的:

在糖尿病伤口愈合的背景下,研究胰岛素对NET形成的影响.
探索胰岛素作为治疗剂的潜力,以调节糖尿病患者的NETs.

主要方法:

在实验室中,在在胰岛素存在或不存在的情况下,用甲酸 (PMA),脂多糖 (LPS) 或离子体 (CI) 刺激后,分析了NET形成.
研究了胰岛素对NET形成的作用机制,包括反应性氧物种的产生,蛋白质酸化和基因素素化.

主要成果:

胰岛素显著延迟了LPS和PMA诱导的NET形成,但没有影响CI诱导的NET形成.
胰岛素的机制涉及诱导反应性氧物种,化p38和ERK,并降低基因组H3的素化.
胰岛素增强了杀死细菌的能力,这表明胰岛素在宿主防御和炎症控制方面发挥了双重作用.

结论:

胰岛素对NET形成具有调节作用,可能为改善糖尿病伤口愈合提供新的策略.
可以探索胰岛素的全身和局部应用,以管理糖尿病中NET相关的并发症.

关键词:

糖尿病糖尿病患者糖尿病患者在这种情况下,胰岛素胰岛素胰岛素.中性粒细胞外细胞陷伤口愈合伤口愈合

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