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衰老在3小时暴露在非常热和干燥的热量中增加了肠细胞损伤:一项初步研究
Josh Foster1,2, Zachary J Mckenna1, Whitley C Atkins1
1Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, The University of Texas Southwestern Medical Center, Dallas, TX 75231, USA.
Biology
|August 26, 2023
概括
与年轻人相比,老年人在极端高温暴露期间经历了更大的胃肠肠细胞损伤. 这项研究强调了热应激对肠道屏障影响的年龄相关差异.
科学领域:
- 环境生理学环境生理学
- 胃肠病学 胃肠病学
- 老年学是一门学科.
背景情况:
- 严重的热应激会损害胃肠道屏障,导致微生物转移和全身炎症.
- 老年人更容易受到与热有关的发病率和死亡率的影响,但与年龄有关的热引起的胃肠道损伤的影响尚不清楚.
研究的目的:
- 调查衰老是否会调节急性热应激期间的肠细胞损伤和全身炎症反应.
- 为了比较3小时的极端高温暴露对年轻人与老年人的肠道屏障完整性和炎症的影响.
主要方法:
- 16名年轻人 (21-39岁) 和16名老年人 (65-76岁) 接受了3小时的暴露在热干燥条件下 (47°C,15%的湿度),间歇性活动 (3METS).
- 肠脂肪酸结合蛋白 (I-FABP),介质蛋白-8 (IL-8) 和组织因子 (TF) 的血度在暴露前和暴露后被测量为肠细胞损伤,炎症和凝血的标志物.
主要成果:
- 年长的成年人显示,与年轻的成年人不同的是,热后暴露的I-FABP (肠细胞损伤标志物) 显著增加.
- 在老年参与者中,I-FABP的增加更大,这表明肠道肠细胞损伤增加.
- 在年轻人中没有观察到IL-8 (炎症标志物) 的显著变化,而老年人则显示下降;TF (凝血标志物) 在年轻人中下降,但在老年人中没有.
结论:
- 老龄化似乎增加了在急性暴露于极端高温期间对肠细胞损伤的易感性.
- 在热应激期间老年人I-FABP升高可能表明胃肠道屏障功能受损.
- 需要进一步的研究来确认这种标志物是否反映了老年人在热应激条件下的肠道透性增加.
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