葡萄皮质类药物及其受体异型:女性生殖,怀孕和胎儿发育中的作用
Sreeparna Bhaumik1, Jack Lockett1,2, James Cuffe3
1Mater Research Institute, Faculty of Medicine, The University of Queensland, Brisbane 4067, Australia.
Biology
|August 26, 2023
概括
葡萄糖皮质体受体 (GRs) 是女性生殖和怀孕的关键. 了解GR变异及其信号对生殖健康和胎儿发育至关重要.
科学领域:
- 内分泌学 在内分泌学.
- 生殖生物学 生殖生物学
- 分子生物学分子生物学
背景情况:
- 垂体-垂体-上腺 (HPA) 轴调节应激反应,涉及葡萄糖皮质体及其受体 (GRs).
- 女性生育器官对女性生育,生殖,胎盘功能和胎儿发育至关重要,在多个层面上影响生殖系统.
- 压力和葡萄糖皮质类药物可能会对生殖和胎儿神经内分泌功能产生负面影响.
研究的目的:
- 审查GRs在女性生育和生殖中的结构和功能.
- 讨论在怀孕期间GRs和葡萄皮质激素信号的作用和变化.
- 整合目前关于GR变异及其对生殖和胎儿生长的影响的知识.
主要方法:
- 在PubMed,科学网络和谷歌学者中进行了广泛的非系统的文献搜索.
- 包括原始研究,元分析和以前的评论论文.
- 综合关于GR结构,功能,变体和信号通路的信息.
主要成果:
- GRs在女性生殖系统中无处不在表达,并调节生殖功能.
- 存在多个GR异型 (例如GRα,GRβ,GRγ,GR-P),通过替代拼接或翻译生成.
- 在胎盘中保存了13种GR异型,这表明它在应激反应和怀孕结果中起着关键作用.
结论:
- GR表达模式可能会影响对葡萄糖皮质激素,妊娠并发症和基于性别的压力变化的差异反应.
- 了解GR变异及其信号对于生殖健康和管理妊娠并发症至关重要.
- 本综述巩固了关于GRs,其变体及其在繁殖和发育中的多方面的作用的当前知识.
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