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血管功能障碍导致COVID-19后的长期认知缺陷

Zahra Shabani^1,2, Jialing Liu³, Hua Su^1,2

¹Center for Cerebrovascular Research, University of California (San Francisco), San Francisco, CA 94131, USA.

|August 26, 2023

概括

严重急性呼吸道综合征冠状病毒2 (SARS-CoV-2) 在许多患者中引起神经症状和认知困难. 这篇评论探讨了SARS-CoV-2诱导的血管功能障碍如何导致长期的大脑雾和神经认知障碍.

科学领域:

神经学神经学
血管生物学血管生物学
传染性疾病传染性疾病

背景情况:

严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2),呼吸系统病毒,可以影响多个器官系统.
神经症状,包括认知困难和"脑雾",在多达三分之二的住院COVID-19患者中是常见的,持续数月.
这些长期的神经认知障碍的潜在机制仍然不完全理解.

研究的目的:

审查当前对COVID-19如何影响血管功能的理解.
阐明SARS-CoV-2引起的血管功能障碍与随后的认知障碍之间的联系.

主要方法:

关于COVID-19,血管功能障碍和神经认知影响的现有研究的文献综述.
综合证据将SARS-CoV-2感染与内皮功能障碍和多器官损伤联系起来.
分析了将血管损伤与认知缺陷联系在一起的拟议机制.

主要成果:

SARS-CoV-2 直接或间接地影响肺外系统的血管系统.
这种血管影响导致内皮功能受损和潜在的多器官损伤.
血管功能障碍是导致COVID-19患者神经认知缺陷的关键途径.

结论:

血管功能障碍是COVID-19后神经认知障碍发展的重要因素.
了解这种联系对于管理长期的"脑雾"和认知衰退至关重要.
需要进一步的研究,以充分阐明机制,并开发有针对性的疗法.

关键词:

这就是SARS-CoV-2病毒.血脑屏障是什么意思认知功能障碍认知功能障碍它们是内皮细胞的内皮细胞.长时间的COVID.神经炎症是一种神经炎症.

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