头向上倾斜睡眠对正静态耐受性的影响:一个范围广泛的审查
Amber H van der Stam1, Sharon Shmuely1, Nienke M de Vries1
1Department of Neurology, Donders Institute for Brain Cognition and Behavior, Radboud University Medical Center, 6500 HB Nijmegen, The Netherlands.
Biology
|August 26, 2023
概括
头向上倾斜的睡眠 (HUTS) 可能会改善正静止性耐受性,例如正静止性低血压和血管. 然而,证据因研究质量和可变性而受到限制.
科学领域:
- 心血管生理学心血管生理学
- 睡眠医学 睡眠医学
- 临床研究方法论 临床研究方法论
背景情况:
- 静止不耐受症影响着许多个体,影响日常生活.
- 头向上倾斜睡眠 (HUTS) 是一种用于管理静态压力的干预措施.
- 关于HUTS有效性的证据需要进行系统的评估.
研究的目的:
- 系统地审查和总结现有证据,以了解头向上倾斜睡眠 (HUTS) 对静态耐受性的影响.
- 评估HUTS对不同患者群体心血管测量的影响.
- 评估研究HUTS的研究质量.
主要方法:
- 在主要数据库 (PubMed,Embase,Cochrane,Web of Science) 进行系统的文献搜索.
- 包括10项研究 (n=185),重点关注静止性低血压,血管,夜间心痛和健康受试者.
- 使用美国神经病学会偏差风险工具进行质量评估.
主要成果:
- 一些对静止性低血压 (OH) 的研究表明,随着HUTS的使用,静止性静止性血压有所改善.
- 静态耐受性似乎在OH中增强,倾斜角度更高 (≥12°),在某些情况下,倾斜角度更小 (5°).
- 在血管中,HUTS增加了对静态应激的弹性,但整体证据质量很弱 (偏差风险很高).
结论:
- 虽然一些生理学迹象表明HUTS对静止性耐受性的潜在好处,但目前的证据很弱.
- 在HUTS协议中的变性,小样本大小和偏差高风险限制了最终的结论.
- 需要进一步的高质量研究来确定HUTS的疗效.
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