现有癌症数据库和确定的需求的最新概述
Brittany K Austin1, Ali Firooz2, Homayoun Valafar2
1Department of Biomedical Sciences, School of Medicine Greenville, University of South Carolina, Greenville, SC 29605, USA.
Biology
|August 26, 2023
概括
对71个癌症数据库的审查发现了显著的增长,但在脂质和糖质数据中发现了关键差距. 需要进一步发展以改善癌症研究资源和可访问性.
科学领域:
- 生物信息学是一种生物信息学.
- 癌症研究 癌症研究
- 数据科学数据科学数据科学
背景情况:
- 现有的癌症数据库对于研究至关重要,但它们的现状和局限性尚未明确.
- 在癌症研究中,了解多组数据 (基因组学,蛋白质组学,脂组学,糖组学) 的可用性和质量至关重要.
研究的目的:
- 评估与癌症相关的数据库的当前状态,重点关注多omics数据.
- 确定癌症数据库资源的关键需求和缺口,特别是脂组学和糖组学.
- 评估现有数据库的公平性 (可查找性,可访问性,互操作性,可重复使用性).
主要方法:
- 对71个现有的癌症数据库进行了全面的搜索.
- 在基因组学,蛋白质组学,脂质组学和糖组学中分析了数据库.
- 包括人类非癌症数据库用于对8年来蛋白质组学,脂组学和糖组学进行比较分析.
- 根据公平原则评估数据库的用户友好性.
主要成果:
- 鉴定出严重缺乏专门的与癌症相关的脂质和糖质数据库.
- 发现了专门用于癌症研究的蛋白质基因数据库数量的局限性.
- 观察到癌症数据库的整体增长,但强调需要开发的特定领域.
- 评估数据库的可查找性,可访问性,互操作性和可重复使用性.
结论:
- 癌症数据库资源已经增长,但仍然存在关键差距,特别是在脂组学和糖组学方面.
- 提高癌症数据库的可访问性,整合性和可用性对于研究进步至关重要.
- 解决这些确定的需求将大大有利于癌症研究人员,临床医生和更广泛的科学界.
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