编辑:"设计瘤免疫微环境"特别版
Raffae N Ahmad1, Scott S Verbridge1
1Department of Biomedical Engineering and Mechanics, Virginia Tech, Blacksburg, VA 24061, USA.
Cancers
|August 26, 2023
概括
癌症免疫疗法显得有前途,但在瘤微环境中面临挑战. 克服这些障碍是提高治疗效率以获得更好的患者结果的关键.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症生物学 癌症生物学
背景情况:
- 癌症免疫疗法具有显著的治疗潜力.
- 瘤微环境 (TME) 对免疫疗法的有效性构成重大障碍.
- 了解TME介导的抵抗机制对于推进癌症治疗至关重要.
研究的目的:
- 研究瘤微环境中的特定障碍,这些障碍限制了癌症免疫治疗的有效性.
- 确定克服TME诱导免疫抑制的新策略.
- 为了提高免疫治疗剂的临床成功.
主要方法:
- 在TME中分析关键的免疫抑制因素.
- 在体外和体外模型来评估免疫治疗反应.
- 开发和测试针对TME组件的组合疗法.
主要成果:
- 确定了抑制抗瘤免疫力的TME的特定细胞和分子组成部分.
- 证明,针对这些TME因素可以恢复免疫细胞功能.
- 在结合免疫治疗与TME调节剂时,在临床前模型中显示出改善的瘤回归.
结论:
- 瘤微环境是癌症免疫治疗结果的主要决定因素.
- 准TME是一种可行的策略,可以提高现有免疫疗法的疗效.
- 对TME调制的进一步研究有望为开发更有效的癌症治疗提供希望.
相关概念视频
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
02:17The Tumor Microenvironment
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
01:27Tumor Immunotherapy
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.