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病理学家评估的多机构评估与免疫评分相比

Joseph Willis¹, Robert A Anders², Toshihiko Torigoe³

¹Department of Pathology, UH Cleveland Medical Center, Cleveland, OH 44106, USA.

|August 26, 2023

概括

标准化免疫评分 (IS) 测定癌症免疫力比专家病理学家的视觉评估更可重复. 数字病理学提供了新一代免疫细胞分析工具.

科学领域:

免疫学免疫学免疫学
数字病理学数字病理学
在瘤学瘤学.

背景情况:

免疫评分 (IS) 是一种数字病理学测试,用于量化癌症患者的免疫反应.
病理学家对免疫细胞透的视觉评估的可复制性对于癌症诊断和治疗至关重要.

研究的目的:

为了比较病理学家对结肠瘤中CD3+和CD8+免疫细胞的视觉评估与定量免疫评分 (IS) 试验的可重复性.
评估视觉T分数和数字IS量化对二类和三类IS分类的一致性.

主要方法:

一个由专家病理学家组成的国际小组评估了来自270例结肠癌病例的540张图像.
在病理学家的T分数,H&E幻灯片和数字IS结果之间进行了对应性分析.
在培训干预之前和之后评估了可重复性.

主要成果:

超过92%的病例显示病理学家之间的T-分数不一致.
视觉评估和数字IS之间的分歧很高 (91-96%),即使是在培训之后.
病理学家和数字IS之间的协同指数较弱,培训后没有显著改善 (卡帕值<0.47).

结论:

与专家病理学家视觉T-score评估相比,标准化的Immunoscore试验显示出更高的可重复性.
数字病理学,特别是Immunoscore测定,代表了下一代工具可再生和定量免疫细胞分析瘤.

关键词:

一个T细胞细胞.解剖病理学解剖病理学结肠癌是什么意思结肠癌是什么意思数字病理学数字病理学免疫评分免疫评分免疫评分预后标志物预后标志物风险分层的分层是风险分层.瘤微环境是一个微环境.

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