与低风险HPV6和HPV11相关的恶性病:系统性审查和癌症预防的影响
Leandro Lima da Silva1, Amanda Mara Teles1,2, Joana M O Santos3
1Post-Graduate Program in Adult Health (PPGSAD), Federal University of Maranhão (UFMA), São Luís 65080-805, MA, Brazil.
Cancers
|August 26, 2023
概括
低风险的人类乳头瘤病毒 (HPV) 类型6和11,通常引起,在阴茎和喉癌中被发现. 这支持HPV疫苗接种,用于更广泛的癌症预防,而不仅仅是生殖器.
科学领域:
- 在瘤学瘤学.
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 高风险的人类乳头瘤病毒 (HPV) 与子宫,生殖器和口腔癌有关.
- 低风险的HPV类型,特别是HPV6和HPV11,主要与生殖器和喉乳头瘤有关.
- 新兴证据表明,HPV6和HPV11也可能导致非宫部位的恶性病变.
研究的目的:
- 为了确定过去十年在各种癌症中单一和双重HPV6 / 11感染的患病率.
- 将HPV6/11的基因组与高风险的HPV16基因型进行比较,确定相似之处和差异.
主要方法:
- 在过去10年内在Cochrane,Embase和PubMed数据库中发表的研究的系统审查.
- 对11篇精选文章的分析,包括1至334名HPV阳性癌症患者的数据.
- 在HPV6/11和HPV16之间进行基因组比较.
主要成果:
- 在0-5.5%的阴茎癌和0-87.5%的喉癌中检测到HPV6/11感染.
- 在,阴道或口腔癌中没有发现HPV6/11感染.
- 基因组分析揭示了HPV6/11和HPV16之间的相似性,主要是在E7基因中,这表明对细胞分化的影响有限.
结论:
- 阴茎和喉癌中HPV6/11的存在支持目前针对这些基因型进行癌症预防的疫苗接种策略.
- 接种HPV6/11疫苗可以保护生殖器和某些癌症.
- 其他风险因素和辅助致癌物可能在HPV相关的上皮癌发生过程中发挥作用.
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