对胃肠道流体瘤的全身治疗选择的评估
Marin Golčić1, Robin L Jones2, Paul Huang3
1Department of Radiotherapy and Oncology, Clinical Hospital Center Rijeka, Krešimirova 42, 51000 Rijeka, Croatia.
Cancers
|August 26, 2023
概括
胃肠道 stromal 瘤 (GIST) 的管理已经发展到有针对性的疗法. 以分子分析为指导的个性化治疗策略,可以改善局部和高级GIST患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 胃肠道 stromal 瘤 (GIST) 是消化道中最常见的介质细胞瘤.
- 外科切除是局部GIST的标准;系统治疗对于转移性或不可切除的疾病至关重要.
研究的目的:
- 审查目前GIST的全身治疗策略.
- 突出分子分析在指导个性化治疗中的作用.
主要方法:
- 对GIST的全身疗法的文献综述.
- 对治疗指南和临床试验数据的分析.
主要成果:
- 伊马替尼是标准的辅助疗法;新辅助的持续时间有所不同 (4-12个月).
- 第一线治疗:伊马替尼布 (标准),阿瓦普利提尼布 (用于PDGFRA D842V),针对NTRK/BRAF的向治疗.
- 第二线:伊马替尼布剂量升级或苏尼替尼布. 第三/第四线:regorafenib和ripretinib. 这两种药物是最常见的.
结论:
- 系统性GIST治疗越来越多地根据分子特征和患者因素进行个性化治疗.
- 多学科护理结合系统性,局部性和支持性治疗对于长期生存至关重要.
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