预测巴西丸癌死亡率的因素:20年的生态研究
Ana Paula de Souza Franco1, Eric Renato Lima Figueiredo1, Giovana Salomão Melo1
1Urogenital System Clinical and Experimental Research Unit, Institute of Health Sciences, Federal University of Pará (UFPA), Belém 66075-110, PA, Brazil.
Cancers
|August 26, 2023
概括
丸癌死亡率在1976年后出生的巴西年轻男性中正在上升,特别是在南方. 农药暴露,特别是杀菌剂和杀虫剂,与丸癌死亡率的增加有关.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 环境健康 环境健康
背景情况:
- 丸癌是年轻男性的重大健康问题.
- 早期检测和多模式治疗对于成功的结果至关重要.
- 了解影响死亡率和生存的因素对于公共卫生干预至关重要.
研究的目的:
- 确定与巴西丸癌死亡率和生存率相关的社会人口统计和风险因素.
- 检查诊断和治疗程序对死亡率的影响.
- 分析两十年来丸癌死亡率的趋势.
主要方法:
- 追溯生态研究分析了巴西 (2001-2020) 丸癌死亡率数据.
- 评估社会人口统计学变量 (婚姻状况,年龄,种族,地区) 和风险因素 (密码主义,农药暴露).
- 统计分析包括年龄标准化死亡率 (ASMR) 和生存率计算.
主要成果:
- 在1976年 (年龄15-40岁) 之后出生的人群中,在2011年后观察到丸癌死亡率的增加趋势.
- 在南方地区,白人和单身人士中发现了更高的ASMR.
- 农药暴露 (杀菌剂,杀虫剂,除草剂) 与ASMR的增加有关,区域差异很大.
- 诊断程序没有减少中西部的ASMR,没有治疗与死亡率有关.
结论:
- 特定的社会人口统计学群体和农药暴露与巴西丸癌死亡率较高有关.
- 当前的诊断和治疗策略可能无法有效地缓解所有地区的死亡率趋势.
- 对高风险人群和环境因素的有针对性的干预措施进行进一步的研究是有必要的.
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