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长期培养FreeStyle 293-F细胞会影响免疫球蛋白G糖的组成

Fran Lukšić1, Anika Mijakovac1,2, Goran Josipović2

  • 1Department of Biology, Faculty of Science, University of Zagreb, 10000 Zagreb, Croatia.

Biomolecules
|August 26, 2023
PubMed
概括

研究了IgG糖体在长细胞传递过程中的稳定性. IgG银河化显示出很高的变异性,突出显示了治疗性抗体生产中需要控制的需要.

关键词:
免费风格 293-F 在线播放在IgG糖基工程方面.通过IgG的糖化.细胞衰老 细胞衰老长期的细胞培养

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Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...